[MIK HOT SPOT_KHIDI] Damage in mitochondria causes disease! Paean Biotechnology presents mitochondriac therapeutic platform

Paean Biotechnology is developing anti-inflammatory and anti-cancer drugs based on mitochondria separated from human umbilical cord-mesenchymal stem cell (UC-MSC).

Paean Biotechnology is developing anti-inflammatory and anti-cancer drugs based on mitochondria separated from human umbilical cord-mesenchymal stem cell (UC-MSC).

Mitochondria therapeutics is a therapeutic agent based on mitochondria separated from stem cells, and includes PN-101 for an inflammatory rare disease called multiple myositis and PN-102 for sepsis.

PN-201 of cell therapeutics is the cell therapeutics using the mitochondria with amplified the anticancer effect by delivering the mitochondria isolated from stem cells into NK cells. Protein therapeutics is a therapeutic agent that uses a technology that uses “modified mitochondria” made by combining PN-301 made by making anti-cancer protein to mitochondria and PN-302 made by marking single antibody chain.

PN-101 has been confirmed for efficacy in a disease animal model and has been tested for toxicity in a GLP institution, and is in the process of preparing an IND for phase 1 clinical trial. PN-102 has been confirmed to have a significant reduction in mortality in animals with sepsis, and the mechanism of regulating immunity due to the cytokine storm in hyperinflammatory conditions and immune paralysis that are immunological characteristics of sepsis.

PN-201 has been confirmed the cancer cell killing ability of mitochondrial-enhanced NK cells and the survival rate increase in animal models, and patents were registered for intracellular mitochondrial delivery and NK cell therapeutics including foreign mitochondria.

The platform technologies of PN-301 and PN-302 include a technique for producing ‘modified mitochondria” by connecting a protein that induces apoptosis of recombinant cancer and a single-chain variable fragment (scFv) antibody to the mitochondrial surface. We have confirmed that “modified mitochondria” targets cancer cells and suppresses tumor growth. Protein delivery technology using mitochondria is an innovative platform technology that can be compared to antibody-drug conjugates that can deliver various types of proteins into cells by targeting cells through scFv.

The products and services of the major companies of KHIDI Health Industry Startup Innovation Center in the MIK Hot Spot (Made in Korea Online Exhibition) will also be displayed in BIO KOREA 2020. Asia’s biggest bio convention BIO KOREA 2020 co-organized by KHIDI and Chungbuk Province and sponsored by MOHW will be open online due to the COVID-29 pandemic on May 18-23. Virtual exhibition halls, conference, and business forums will be operated, and the companies will be promoting their competitiveness. Also, with video meetings, businesses between overseas speakers, buyers, and domestic and foreign participating companies will be made. To date, more than 160 companies have applied for the virtual exhibition booth at BIO KOREA 2020. Companies wishing to participate can apply through the web page or email by Apr. 30.

The global news network AVING News has begun holding the MIK Hot Spot (Made in Korea Online Exhibition) to help small and medium-sized companies enter the market and attract investment 365 days a year. AVING News has been running online exhibitions since 2005 and had 975 online exhibitions so far. Its YouTube online exhibition has placed itself as Korea’s largest online exhibition hall that opens with 19,000 videos (booths) with more than 800,000 visits per month which means more than 10 million visits per year.

The MIK Hot Spot online exhibition is scheduled to be held regularly according to the field, target market, and participating institutions, and it will be presented as a new type of online business by transforming the know-hows and values of the participating companies according to the trend. Companies that want to participate can apply and apply through the marketing support projects from supporting institutions in the local governments. Refer to the institutions for more information.

→ Go to MIK Hot Spot (Made in Korea Online Exhibition) special page

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